Letter by Navarro Castellanos and Dahdah Regarding Article, “Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic”

HomeCirculationVol. 143, No. 10Letter by Navarro Castellanos and Dahdah Regarding Article, “Acute Heart Failure in Multisystem Inflammatory Syndrome Children the Context of Global SARS-CoV-2 Pandemic” Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessLetterPDF/EPUBLetter Iñaki Nagib CastellanosIñaki https://orcid.org/0000-0002-7680-0835 Pediatric Cardiology Department, CHU-Saint Justine, Université de Montréal, Quebec, Canada. Search for more papers this author DahdahNagib Originally published8 Mar 2021https://doi.org/10.1161/CIRCULATIONAHA.120.049239Circulation. 2021;143:e759–e760To Editor:We read with interest article Belhadjer et al1 are grateful effort rapidly advance knowledge clinical presentations associated novel coronavirus. In light our reading interpretation content article, we request that authors clarify some points.What causes Kawasaki disease (KD) is still not known, but there evidence a transitory autoimmune response after an external exposure infectious agents, such as viral respiratory infections.2 The entity known KD shock syndrome, described initially series Dominguez al3 2008 later suggested case definition Kanegaye al4 2009, has many similarities multisystem inflammatory syndrome children hemodynamic instability, impaired left ventricle (LV) function, what seems greater incidence coronary artery abnormalities, higher C-reactive protein concentrations, intravenous immunoglobulin resistance. From perspective, it would have been helpful reader future utility paper (for meta-analysis statistics, instance) if criteria were made available table possible associative statistics patient outcomes.In Discussion original argue one main difference between patients LV dysfunction was present all compared only one-third syndrome. Because inclusion criterion children, simply spurious. Other minor or laboratory differences could be result small sample size, aspect believe should mentioned.From another inconsistency normal ejection fraction because initial classification defined <50%, Table 2, cutoff 60%. addition, results 2 show recovery at day 7, whereas shown text mention days. Also, like whether other parameters strain, E/a ratio, E/e’ ratio used myocardial classification. Along same lines, found surprising how placed under extracorporeal mechanical support/mechanical assistance, clarify. More precisely, led support?Overall, brought valuable information. We sincerely hope they can address points better clarity among uncertainties during pandemic.Disclosures None.Footnoteshttps://www.ahajournals.org/journal/circReferences1. Z, Méot M, Bajolle F, Khraiche D, Legendre A, Abakka S, Auriau J, Grimaud Oualha Beghetti Met al. Acute heart failure context global pandemic.Circulation. 2020; 142:429–436. doi: 10.1161/CIRCULATIONAHA.120.048360LinkGoogle Scholar2. McCrindle BW, Rowley AH, Newburger JW, Burns JC, Bolger AF, Gewitz Baker AL, Jackson MA, Takahashi Shah PBet al; American Association Rheumatic Fever, Endocarditis, Disease Committee Council on Cardiovascular Young; Stroke Nursing; Surgery Anesthesia; Epidemiology Prevention. Diagnosis, treatment, long-term management disease: scientific statement health professionals from Association.Circulation. 2017; 135:e927–e999. 10.1161/CIR.0000000000000484LinkGoogle Scholar3. SR, Friedman K, Seewald R, Anderson MS, Willis L, Glodé MP. pediatric intensive care unit: case-control study.Pediatrics. 2008; 122:e786–e790. 10.1542/peds.2008-1275CrossrefMedlineGoogle Scholar4. JT, Wilder Molkara Frazer JR. Recognition syndrome.Pediatrics. 2009; 123:783–789CrossrefMedlineGoogle Scholar eLetters(0)eLetters relate recently published journal forum providing unpublished data. Comments reviewed appropriate use tone language. peer-reviewed. Acceptable comments posted website only. issue indexed PubMed. no longer than 500 words will online. References limited 10. Authors cited comment invited reply, appropriate.Comments feedback AHA/ASA Scientific Statements Guidelines directed Manuscript Oversight via its Correspondence page.Sign Submit Response This Article Previous Back top Next FiguresReferencesRelatedDetails March 9, 2021Vol Issue 10 Advertisement InformationMetrics © 2021 Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.120.049239PMID: 33683948 publishedMarch 8, PDF download SubjectsNuclear PETThrombosis